"Expression of 5'-deiodinase enzymes in normal pituitaries and in various human pituitary adenomas". Baur A, Buchfelder M, Köhrle J (2002)."The mRNA structure has potent regulatory effects on type 2 iodothyronine deiodinase expression". Gereben B, Kollár A, Harney JW, Larsen PR (2003)."Substitution of cysteine for a conserved alanine residue in the catalytic center of type II iodothyronine deiodinase alters interaction with reducing cofactor". Kuiper GG, Klootwijk W, Visser TJ (2002)."Inhibition of type 2,5'-deiodinase by tumor necrosis factor alpha, interleukin-6 and interferon gamma in human thyroid tissue". Molnár I, Balázs C, Szegedi G, Sipka S (2002)."Type 2 iodothyronine deiodinase expression is upregulated by the protein kinase A-dependent pathway and is downregulated by the protein kinase C-dependent pathway in cultured human thyroid cells". "Identification of two novel splicing variants of human type II iodothyronine deiodinase mRNA". "Distinct subcellular localization of transiently expressed types 1 and 2 iodothyronine deiodinases as determined by immunofluorescence confocal microscopy". Baqui MM, Gereben B, Harney JW, et al."Characterization of the 5'-flanking and 5'-untranslated regions of the cyclic adenosine 3',5'-monophosphate-responsive human type 2 iodothyronine deiodinase gene". "The 3'-untranslated region of human type 2 iodothyronine deiodinase mRNA contains a functional selenocysteine insertion sequence element". Buettner C, Harney JW, Larsen PR (1999)."Large-scale concatenation cDNA sequencing". "Type 2 iodothyronine deiodinase is highly expressed in human thyroid". Salvatore D, Tu H, Harney JW, Larsen PR (1996)."A "double adaptor" method for improved shotgun library construction". Andersson B, Wentland MA, Ricafrente JY, et al."Pretranslational regulation of type 2 deiodinase". "Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation". ^ Curcio-Morelli C, Zavacki AM, Christofollete M, Gereben B, de Freitas BC, Harney JW, Li Z, Wu G, Bianco AC (July 2003).^ a b "Entrez Gene: DIO2 deiodinase, iodothyronine, type II"."Assignment of type II iodothyronine deiodinase gene (DIO2) to human chromosome band 14q24.2→q24.3 by in situ hybridization".
^ Croteau W, Davey JC, Galton VA, St Germain DL (Sep 1996).National Center for Biotechnology Information, U.S. Interactions ĭIO2 has been shown to interact with USP33. Alternative splicing results in multiple transcript variants encoding different isoforms. The 3' UTR of Sec-containing genes have a common stem-loop structure, the Sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T 3 production in patients with Graves' disease and thyroid adenomas. It activates thyroid hormone by converting the prohormone thyroxine (T 4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T 3). The protein encoded by this gene belongs to the iodothyronine deiodinase family.
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